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The perform of SIK1 in tumorigenesis. SIK1 is a tumor suppressor gene, which plays a significant regulatory role in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and affects cancer mobile proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 might also market most cancers c
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